معرفی
Marella de Bruijn is a Professor of Developmental Haematopoiesis at the University of Oxford, where she leads research at the MRC Molecular Haematology Unit within the MRC Weatherall Institute of Molecular Medicine. She also serves as the Director of Graduate Studies for the Radcliffe Department of Medicine and WIMM, mentoring DPhil students and postdocs. Her academic journey includes a BSc from Leiden University, a PhD from Erasmus University, and postdoctoral training at Erasmus University and Dartmouth Medical School.
- University: University of Oxford
- School: Radcliffe Department of Medicine
- Department: MRC Molecular Haematology Unit
Her research centers on the birth of blood stem and progenitor cells during embryonic development, with a focus on cellular lineages, gene regulatory networks, and the role of transcription factors like Eomesodermin and Runx1. She explores how epigenetic regulators such as Ezh2 and chromatin dynamics influence hematopoiesis, aiming to advance stem cell therapies for regenerative medicine and blood disorders.
- Research Themes: Hematopoiesis, Developmental Biology, Gene Regulatory Networks, Stem Cell Niche, Epigenetics
- Key Technologies: CRISPR screening, ChIP-seq, Mouse and Zebrafish Models
Recent publications highlight her work on hemogenic endothelium (2024), dynamic chromatin boundaries (2022), and the epigenetic role of Ezh2 (2021), among others. Her studies also address apoptosis resistance in leukemia and trisomy 21 effects on hematopoiesis.
The MRC Molecular Haematology Unit under her leadership investigates the molecular mechanisms of blood stem cell formation, collaborating with teams like the Radcliffe Department of Medicine and WIMM. She integrates transcription factor network analysis with functional assays to uncover therapeutic targets.