معرفی
Claus Nerlov is a Professor of Stem Cell Biology at the University of Oxford, based at the MRC Weatherall Institute of Molecular Medicine within the Radcliffe Department of Medicine. He leads the Nerlov Group, focusing on single cell biology and genetics of hematopoietic stem and progenitor cells in blood cancer and aging.
His research centers on hematopoiesis, leukemogenesis, and aging through genetic methods, genome-wide expression, and chromatin profiling. Key areas include stem cell niche maintenance, lineage commitment regulation by transcription factors, and molecular mechanisms of acute myeloid leukemia. His work aims to develop cell-based and molecular therapies for blood disorders by understanding normal, aging, and malignant hematopoiesis.
The Nerlov Group operates within the MRC Molecular Haematology Unit, utilizing advanced single-cell technologies to dissect hematopoietic complexity. Their recent publications reveal trends in stem cell heterogeneity, epigenetic regulation, clonal hematopoiesis, and niche-derived factors in aging, spanning hematology, immunology, and molecular biology. The group's work integrates stem cell biology with translational applications for blood malignancies and age-related decline.