Stefania Filosa

Stefania Filosa is a Research Director at the Institute of Biosciences and BioResources (IBBR), National Research Council of Italy (CNR), Naples Division. She leads a research unit at IRCCS Neuromed, Pozzilli, focusing on oxidative stress in neurodevelopmental disorders. Her academic background includes a PhD in Veterinary Pharmacology and Toxicology and a Laurea in Biological Sciences from the University of Naples 'Federico II'.

• PhD in Veterinary Pharmacology and Toxicology, University of Naples 'Federico II', 1993
• Laurea in Biological Sciences, summa cum laude, University of Naples 'Federico II', 1989

Her research centers on oxidative stress, particularly the role of Glucose-6-phosphate dehydrogenase (G6PD) and NADPH in apoptosis, differentiation, and neurodevelopment. She utilizes genetically modified embryonic stem cells to model diseases like Rett Syndrome and Huntington's disease. Her recent work investigates the neuroprotective effects of natural compounds such as curcumin, Ginkgo biloba, and polyphenols, exploring their impact on the gut-brain axis and neurodegeneration. She has been a Group Leader since 2001, a CNR Senior Researcher since 2007, and has led a Research Unit at IRCCS Neuromed since 2015.

Her extensive publication record over the past five years reveals a strong focus on the therapeutic potential of dietary bioactives. Her research trends involve studying polyphenols, curcumin, and marine compounds for their anticancer and neuroprotective properties, using in vitro and in vivo models of mesothelioma, Huntington's disease, and Alzheimer's disease. She frequently explores mechanisms involving oxidative stress, apoptosis, and gut microbiota interactions, with a growing interest in epigenetic regulation in neurodevelopmental disorders like those linked to ARX and KDM5C genes.

Stefania Filosa has no explicitly mentioned scientific awards in the provided texts.

She has led her own research group since 2001 and has mentored numerous collaborators, though specific names of her formal PhD or Master's students are not listed in the provided texts. Her work has been supported by long-term funding from institutions like Telethon and CNR, and she has been involved in various national and international research projects. Her current research at IRCCS Neuromed focuses on oxidative stress in Rett Syndrome, and she collaborates extensively, particularly with Stefania Crispi.

She is associated with the Stem Cell Fate Lab at the Institute of Genetics and Biophysics 'Adriano Buzzati Traverso' and leads a research unit at IRCCS Neuromed, Pozzilli. Her team investigates molecular pathways in neurodevelopmental and neurodegenerative disorders, utilizing stem cell models and testing natural therapeutic compounds.