معرفی
Srivatsan Raman is an Associate Professor at the University of Wisconsin–Madison, with appointments in the Department of Bacteriology and as an affiliate in the Department of Chemical and Biological Engineering. He is also affiliated with the Great Lakes Bioenergy Research Center and the Center for Genome Science Innovation.
Education:
- B.S., Baroda University, India
- M.S., Missouri University of Science and Technology
- Ph.D., University of Washington, Seattle
- Postdoctoral, Harvard Medical School - Wyss Institute for Biologically-inspired Engineering
His research lies at the intersection of systems biology, synthetic biology, and computational biology, with a focus on protein allostery, bacteriophage engineering, and high-throughput functional genomics. He develops and applies deep mutational scanning, chip-based DNA synthesis, and machine learning to understand and design biological systems at scale. His lab pioneers methods to reprogram phages for antibacterial therapy and microbiome editing, and to dissect the functional impact of human genetic variants.
The recent publications reflect a strong trend in engineered biological systems, particularly in phage engineering, allostery, and functional genomics. These works span primary research and authoritative reviews in top journals, demonstrating both technical innovation and thought leadership.
Scientific Contributions:
- Developed frameworks for engineering allostery and biosensors
- Pioneered high-throughput phage genome engineering
- Advanced deep mutational scanning for variant effect prediction
- Designed programmable phages with controllable infectivity
Raman leads a multidisciplinary research program that bridges fundamental science with translational applications in health and biotechnology. His lab leverages cutting-edge technologies to train machine learning models for protein and genome design. While student names are not listed, his group clearly mentors trainees in synthetic biology and genomics. His work is supported by affiliations with major research centers, indicating substantial grant funding and collaborative networks.
Laboratory & Research Themes:
- Raman Laboratory: Focuses on protein allostery, phage-host interactions, and human disease variants
- Technologies: Deep mutational scanning, pooled screening, computational design (Rosetta), single-cell RNA-seq
- Emerging Areas: Transporters, gene delivery systems, vaccine design
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