Kenneth Matreyek

Kenneth Matreyek is an Assistant Professor in the Department of Pathology at Case Western Reserve University's School of Medicine. He is also a member of the Cleveland Center for Membrane & Structural Biology. His research focuses on developing genetic technologies to study protein sequence variants and their impacts on disease. He holds a BSc in Microbiology, Immunology, and Molecular Genetics from UCLA, a PhD in Virology from Harvard University, and completed postdoctoral training in Genome Sciences at the University of Washington.

Research Interests: The Matreyek Lab investigates how protein variants contribute to disease using mammalian synthetic biology to create multiplex genetic assays. Key areas include:

• Characterization of germline/somatic missense variants
• Infectious disease/viral biology (e.g., HIV, SARS-CoV-2)
• Systematic analysis of protein domains and peptide motifs
• Drug metabolism variant impacts
• Directed evolution of novel proteins

Publications: Recent work includes high-throughput studies of SARS-CoV-2 spike protein mutations, ACE2 receptor dependencies, and functional screening of protein variants. His lab's approach combines synthetic biology with high-throughput sequencing to address fundamental biological questions.

Labs/Teams: Leads the Matreyek Lab, which operates out of the CWRU School of Medicine. Collaborates with virology, synthetic biology, and clinical genomics groups. Lab website: MatreyekLab.com