معرفی
Dr. Matteo Ferla is a Postdoctoral Researcher at the University of Oxford's Department of Biochemistry, affiliated with the Oxford Protein Informatics Group. His research focuses on computational biochemistry, drug design, and molecular thermodynamics, with a growing interest in deep learning applications. He develops tools like Fragmenstein (for fragment-based drug discovery), Michelanglo (protein structure visualization), and Venus (variant functional analysis). His work bridges structural biology, bioinformatics, and experimental validation, contributing to understanding protein-ligand interactions, genetic variants' effects, and drug development.
Key Projects:
- Fragmenstein: A computational tool stitching molecules for drug discovery.
- Michelanglo: Web-based protein structure annotation platform.
- Venus: Analyzes missense variants' functional impacts beyond structural destabilization.
Research Themes:
- Fragment-based drug design.
- Computational methods for protein engineering.
- Genetic and structural basis of rare diseases.
Publications: Over 20 peer-reviewed articles, including high-impact contributions to Science, Genome Medicine, and Brain, focusing on SARS-CoV-2 inhibitors, genetic disorder mechanisms, and structural biology tools.
