معرفی
Professor Joe Marsh is a Personal Chair of Computational Protein Biology at the University of Edinburgh, affiliated with the Institute of Genetics and Cancer and leading the MRC Human Genetics Unit. His research focuses on computational methods to study protein complexes in normal biological processes and human disease.
- Education:
- BSc, University of British Columbia (2003)
- PhD, University of Toronto (2009)
His research explores the molecular mechanisms of protein variants in disease, emphasizing gain-of-function and dominant-negative effects. He uses structural bioinformatics, computational variant prediction, and deep mutational scanning (in collaboration with the Kudla lab) to understand pathogenic mutations and improve variant effect prediction. His work also investigates protein complex assembly, regulation, and evolution through structural, genomic, and proteomic datasets.
Recent publications highlight his group's contributions to structural biology, including studies on:
- Cotranslational assembly of protein complexes
- Differential effects of mutation types on protein structure
- Evolution of allostery in protein complexes
- Quaternary structure's role in disease mutations
- Binding site dynamics and stoichiometry in aneuploid cells
Scientific recognition includes:
- 2018 - Lister Institute Research Prize
- 2019 - Patrick Neill Medal
He advises PhD students:
- Hasan Çubuk
- Mohamed Fawzy
- Ankit Pathak
- Verena Obermuller
- Rowena Tao
- Yifei Shang
Current projects include Protein variant interpretation (2023-2028) and collaborative efforts like Precision control of protein dosage in vivo funded by the Medical Research Council (MRC) and European Commission. His research themes span protein complexes, structural bioinformatics, genetic variation, and evolution.
