Simon Tang

Simon Tang is an Associate Professor in Orthopaedics at Washington University in St. Louis, where he directs a research program integrating musculoskeletal bioengineering and regenerative medicine. His work addresses fundamental questions in tissue degeneration while developing therapeutic strategies for clinical translation.

Primary research themes include:

• Mechanisms of intervertebral disc degeneration and regeneration
• Advanced glycation end-products in musculoskeletal tissues
• Bone quality assessment using novel imaging and biomechanical tools
• Tissue-level effects of aging and radiation

His laboratory utilizes diverse methodologies including contrast-enhanced microCT, single-cell RNA sequencing, mechanical testing, and finite element modeling. Current projects explore TRPV4 modulation for disc protection and novel diagnostics for fracture risk assessment.