Simon Kobelke

Simon Kobelke is a Research Officer at the School of Human Sciences, The University of Western Australia. His research focuses on molecular mechanisms of nuclear organization, particularly involving RNA-binding proteins and subnuclear structures.

His research interests span across several key areas in molecular biology:

• RNA-binding proteins and their roles in cellular organization
• Paraspeckle formation and function
• Phase separation in biomolecular condensates
• Mechanisms of RNA processing and regulation
• Connections between nuclear organization and cancer

Kobelke's recent publications demonstrate a strong focus on how RNA-binding proteins like SFPQ, NONO, and other DBHS family members organize nuclear architecture through phase separation. His work connects fundamental molecular mechanisms with disease processes, particularly in cancer biology. The research shows how low-complexity regions in proteins drive biomolecular condensate formation and how G-quadruplex DNA structures influence paraspeckle assembly in cancer cells.

His work contributes to the UN Sustainable Development Goals related to good health and well-being, with potential implications for understanding disease mechanisms at the molecular level.

Kobelke collaborates extensively with researchers across institutions, particularly with the Fox and Bond laboratories, focusing on the biochemical and structural aspects of RNA-protein interactions and their cellular consequences.