Archa Fox

Archa Fox is a Professor in the School of Human Sciences and the School of Molecular Sciences at the University of Western Australia, and an Honorary Research Fellow at the UWA Medical School and UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research). She is also part of the Australian Centre for RNA Therapeutics in Cancer and serves as Chair of the RNA Network of Australia since 2015. Her research has significantly advanced the understanding of nuclear architecture and RNA biology.

Professor Fox earned her Bachelor of Science at the University of New South Wales, majoring in molecular genetics, followed by her PhD at the University of Sydney (awarded in 2000). She completed postdoctoral research in Dundee, Scotland, where she integrated cell biology, microscopy, and molecular biology techniques. In 2006, she established her research group at the Western Australian Institute for Medical Research (now the Harry Perkins Institute), and in 2015, she transitioned to an academic position at the University of Western Australia.

Her research centers on paraspeckles, nuclear bodies she discovered in 2002 that play crucial roles in gene expression regulation. Her work has revealed how paraspeckles malfunction in diseases like cancer. In 2009, she identified NEAT1 as the first long noncoding RNA that scaffolds a nuclear body, and in 2015, she demonstrated how intrinsically disordered protein regions contribute to paraspeckle formation. Her current research investigates paraspeckles as a model for understanding gene regulation through long noncoding RNAs and protein aggregation, with collaborations across multiple scientific disciplines.

Analysis of Professor Fox's recent publications (2022-2025) reveals a strong focus on nuclear architecture, RNA-binding proteins, and the molecular mechanisms of paraspeckle formation and function. Her work spans structural biology, cancer research, and the emerging field of biomolecular condensates, with particular emphasis on DBHS family proteins (SFPQ, NONO, PSPC1) and their roles in phase separation and nuclear organization.

Scientific Awards:

• Marshall Medal of the Harry Perkins Institute (2012)
• Emerging Leader Award of the Australian/NZ Society for Cell and Developmental Biology (2017)
• School of Human Sciences Senior Research Award (2023)
• Vice Chancellor's Senior Research Award (2023)
• UWA Student Guild's Students' Choice Awards (2018)

Professor Fox has been actively involved in mentoring and research leadership, with 8 supervised works documented. She has secured significant research funding, including 48 grants such as the 'STUNNER for RNA encapsulation quality and deliver' project funded by The Ian Potter Foundation (2024-2025) and the 'WA RNA Salon' project funded by The RNA Society (2024-2025). Her collaborative approach is evident in multi-investigator projects like the 'Broadening assay capabilities with CLARIOstar Plus multimode platereader' (2025-2035).

Her laboratory forms part of the Australian Centre for RNA Therapeutics in Cancer and maintains strong affiliations with the Harry Perkins Institute of Medical Research. Professor Fox has also been instrumental in community engagement, participating in the Wembley Primary School Community STEAM program and Pint of Science presentations, demonstrating her commitment to science communication and public outreach.