Shenglin Mei
استادیار · Computational Biology
Virginia Polytechnic Institute and State Universityمعرفی
Shenglin Mei, Ph.D., is an Assistant Professor at the Fralin Biomedical Research Institute (FBRI) at Virginia Tech and the Department of Biomedical Sciences and Pathobiology at the Virginia-Maryland College of Veterinary Medicine. His lab is based at the Children's National Research & Innovation Campus in Washington, D.C., where he leads research on tumor microenvironment remodeling during cancer metastasis.
Dr. Mei holds a Ph.D. in Bioinformatics from Tongji University and completed postdoctoral training at Harvard Medical School and Massachusetts General Hospital. His research integrates computational biology, single-cell genomics, spatial transcriptomics, and machine learning to study the molecular mechanisms of tumor progression and metastasis.
His research interests include:
- Computational methods for multi-omics data integration (scRNA-seq, scATAC-seq, spatial transcriptomics)
- Context-dependent remodeling of the tumor microenvironment
- Identification of novel regulators in cancer metastasis
- Organ-specific metastasis mechanisms
- Development of therapeutic strategies for metastatic cancers
Dr. Mei's recent publications focus on metastatic cancers such as neuroblastoma, renal cell carcinoma, and prostate cancer, utilizing single-cell and spatial technologies to dissect immune and stromal remodeling in primary and metastatic tumors. His work has revealed key immunosuppressive mechanisms and potential therapeutic targets in the tumor microenvironment.
Scientific awards and honors include:
- Young Investigator Award, Royalty Pharma-Prostate Cancer Foundation (2023–2026)
- Challenge Award, Michael & Lori Milken Family Foundation-Prostate Cancer Foundation (2022–2025)
- Outstanding Graduates Award, Nanjing Agricultural University (2012)
Dr. Mei has secured significant research funding and leads an active lab focused on computational cancer genomics. He is actively mentoring postdoctoral fellows and graduate students, and his lab collaborates with multiple institutions. The Mei Lab is currently recruiting talented researchers to advance computational methods and biological discovery in cancer metastasis.
His research team is based at the Children's National Research & Innovation Campus, contributing to the Cancer Research Center - D.C., and is part of the Children's National Center for Cancer and Immunology Research.
