Matti Nykter

Matti Nykter is a Professor of Bioinformatics at the Faculty of Medicine and Health Technology within the Department of Biomedicine at Tampere University. His research focuses on computational biology, cancer genomics, and systems medicine with an emphasis on prostate cancer, gliomas, and epigenetic mechanisms.

Key areas of investigation include:

• Cancer evolution and therapeutic resistance using liquid biopsy approaches
• Integration of multi-omics data (genomics, epigenomics, transcriptomics)
• Bioinformatic methods for analyzing tumor heterogeneity and clonal evolution
• Zebrafish models for studying host-pathogen interactions

His work bridges basic science and clinical applications, developing biomarkers and computational tools for precision oncology. Recent studies explore immunogenomics of cancer, single-cell profiling of tumor microenvironments, and molecular characterization of metastatic progression.

Major contributions include:

• Epigenetic profiling of endocrine-resistant prostate cancer
• Genomic analysis of Lynch syndrome-associated cancers
• Development of UCLIB diagnostic panel for non-invasive cancer detection
• Identification of therapeutic targets via single-cell and spatial transcriptomics