Sandra L Grimm

Sandra L. Grimm, Ph.D., is an Instructor in the Department of Molecular and Cellular Biology at Baylor College of Medicine. Her research focuses on understanding molecular mechanisms underlying genetic disorders, environmental exposures' epigenetic impacts, and translational applications in cancer and immunology. She investigates pathways such as DNA methylation, metabolomics, and gene expression regulation across diverse systems including lung injury, cardiac dysfunction, and microbiome interactions.

Her work integrates cutting-edge techniques like single-cell transcriptomics, reverse-phase protein arrays, and multi-omics approaches to uncover disease mechanisms. Key projects include studying epigenetic reprogramming in early-life exposures, therapeutic resistance in idiopathic pulmonary fibrosis, and biomarker development for hepatocellular carcinoma. Dr. Grimm's research also addresses ethnic disparities in conditions like uterine fibroids through extracellular matrix analysis.

Publications highlight her expertise in gene-environment interactions, nuclear receptor signaling, and tumor biology with applications to breast cancer, prostate cancer, and tuberculosis. Her interdisciplinary approach bridges basic science and clinical translation, emphasizing personalized medicine and host-directed therapies.