Fiona Oakley

Professor Fiona Oakley is a leading academic at Newcastle University's Faculty of Medical Sciences, specializing in liver pathophysiology. Her research focuses on molecular mechanisms driving liver fibrosis, hepatocellular carcinoma, and metabolic disorders, with emphasis on NF-κB signaling, cellular senescence, and epigenetic regulation. She employs preclinical models to develop therapeutic strategies targeting fibrosis progression and tumorigenesis.

Her investigations span:

• Fibrosis pathogenesis via TGF-β, HDACs, and extracellular matrix dynamics
• Metabolic dysfunction in steatotic liver disease (MASLD)
• Senescence-mediated multi-organ dysfunction
• Immunological defenses against liver cancer (e.g., TREM-2)

Recent publications (2023–2025) highlight innovations in 3D tumor modeling, spatial lipidomics, and necroptosis signaling. Her work consistently bridges basic science with translational applications, though specific grant/student details are undisclosed.