معرفی
Rebecca D. Burdine is a Professor in the Department of Molecular Biology at Princeton University, where she leads a research laboratory focused on developmental mechanisms of left-right patterning and organ morphogenesis using zebrafish as a model organism. Her work bridges molecular genetics, cell biology, and human disease modeling, with a strong emphasis on understanding congenital disorders.
Education:
- B.S., Western Kentucky University (summa cum laude), Recombinant Gene Technology
- Ph.D., Yale University, Molecular Biophysics and Biochemistry
- Postdoctoral Training, NYU (Skirball Institute), Harvard (Schier Lab)
Dr. Burdine’s research investigates how vertebrates break embryonic symmetry to establish internal left-right asymmetry, focusing on cilia-driven fluid flow, asymmetric gene expression (e.g., Nodal, Pitx2), and downstream organ morphogenesis. Her lab explores the genetic and cellular basis of congenital heart defects, ciliopathies, RASopathies, and idiopathic scoliosis. Using zebrafish, her team employs live imaging, genomic approaches, and disease modeling to dissect signaling pathways and validate human variants.
Her recent publications demonstrate a consistent focus on TGFβ signaling (Nodal, Gdf3), RAS/MAPK pathway regulation, cilia function, and the integration of embryo-scale and organ-intrinsic asymmetries. Themes across her work include signal transduction dynamics, post-transcriptional regulation, and the use of zebrafish for functional validation of human disease genes.
Scientific Awards and Honors:
- Elected Fellow, AAAS (2018)
- 44th Mallinckrodt Scholar (2003–2006)
- American Heart Association Scientist Development Award (2003–2006)
- Clio Hall Award, Princeton (2024)
- National Academies Education Fellow (2013–2014)
Dr. Burdine actively mentors students and has advised graduate researchers such as Cullen B. Young. She serves on the editorial board of Zebrafish and grant review panels for NIH and NSF. She is a leader in the Angelman Syndrome Foundation, where she chairs the Science Advisory Committee, combining personal and scientific dedication to neurodevelopmental disorders. Her lab fosters collaboration, rigorous methodology, and translational impact.
