Rafael Brüschweiler

Rafael Brüschweiler is a Professor and Ohio Research Scholar at The Ohio State University, holding joint appointments in the Department of Chemistry and Biochemistry and the Department of Biological Chemistry and Pharmacology. He serves as the NMR Executive Director for the Ohio State Campus Chemical Instrument Center and the NSF-funded National Gateway Ultrahigh Field NMR Center. His research focuses on biophysical chemistry, analytical chemistry, and computational modeling, emphasizing protein dynamics, metabolomics, and NMR method development. He received his Ph.D. from ETH Zurich and completed a postdoc at the Scripps Research Institute.

His research integrates experimental NMR, molecular dynamics simulations, and machine learning to study protein structure-function relationships, metabolic pathways, and biomolecular interactions. Key areas include the dynamics of oncogenic K-Ras, glucokinase glucose sensing, and nanoparticle-assisted NMR techniques. His work is funded by the NIH and NSF, with applications in biomedical diagnostics and drug discovery.

Dr. Brüschweiler leads a multidisciplinary lab training students and postdocs in NMR spectroscopy, computational methods, and metabolomics. His lab developed tools like DEEP picker and COLMAR for automated NMR data analysis, contributing to the SECIM metabolomics center. He actively recruits students interested in protein dynamics, computational modeling, or metabolomics.