معرفی
Rachel Golub is a Professor of Immunology at Université Paris Diderot (Paris 7) and heads the Lymphopoiesis Unit at the Institut Pasteur, INSERM U668, in Paris. Her research centres on innate lymphoid cell (ILC) biology, Notch signalling, and their implications in liver cancer, inflammation, and tissue regeneration.
Education:
- PhD in Developmental Biology, Université Paris 6, 1997
- HDR (Habilitation), Université Paris 7, 2007
Research Interests:
Professor Golub investigates how innate lymphoid cells develop from fetal and adult progenitors, the molecular circuits controlled by the Notch pathway that balance ILC subsets, and how these pathways influence hepatocellular carcinoma progression and inflammatory diseases. Her team combines single-cell approaches, genetically modified models, and human tissue analysis to dissect microenvironmental cues shaping ILC fate.
Publication Trends:
Between 2020 and 2024 her work has appeared in leading journals such as Cell Reports, Immunity, EMBO Journal, Blood, and Frontiers in Immunology. The studies cluster around four main axes: (1) ILC differentiation and ontogeny, (2) Notch-mediated regulation of ILC and NK cells, (3) tumour-immune interactions in hepatocellular carcinoma, and (4) inflammatory modulation of lymphocyte development in metabolic and wound-healing contexts.
Scientific Awards & Recognition:
- Prime d’Excellence Scientifique (PES) 2012-2016
- PEDR Award 2007-2011
- INSERM CSS7 third-rank distinction 2014
- Fellowships from Ligue Nationale contre le Cancer, MRC Canada, Ontario Cancer Institute, and French Ministry of Research
Grants & Advising:
She has served as coordinator or collaborator on >15 major grants (ANR, ARC, INCA, FACCTS, USPC, ABM, PTR), funding post-doctoral and doctoral students as well as collaborative international projects. She regularly sits on HDR and PhD juries, ANR panels, and foreign funding agencies (DFG).
Labs & Teams:
Her Lymphopoiesis Unit at Institut Pasteur hosts the “ILC Development and Inflammation” group, currently comprising PhD students, engineers, and technicians. The team is embedded within the wider Pasteur Immunology Department and benefits from institute-level platforms such as Single-Cell Biomarkers and advanced imaging core facilities.
