معرفی
James Di Santo is a leading researcher and Structure Manager at the Institut Pasteur, where he heads projects within the Innate Immunity Unit (Inserm U1223). He leads a vibrant research group focused on innate lymphoid cells, immune development, and host responses to infectious diseases. His work bridges fundamental immunology and translational applications using advanced mouse models.
His research interests span innate immunity, development of the immune system, innate lymphoid cells (ILCs), mucosal immunity, infectious diseases (including HIV, TB, malaria, and hepatitis), and humanized mouse models. His work explores the molecular and cellular mechanisms underlying immune responses, with implications for vaccinology and anticancer immunity.
His recent publications reflect a strong focus on ILC biology, immune signaling (e.g., IL-7, Notch, RORC), host-pathogen interactions (particularly HIV and mycobacteria), and the development of sophisticated animal models. The research trends emphasize mechanistic insights into immune cell differentiation, function, and regulation in health and disease.
His scientific awards include the prestigious ERC-2015-AdG ILC_REACTIVITY grant, highlighting the significance and innovation of his work in innate lymphoid cell biology.
James Di Santo actively mentors the next generation of scientists, supervising numerous PhD students and postdoctoral fellows. His research is supported by major grants, including ERC funding, enabling cutting-edge projects in immunology and infectious disease modeling. He is a key figure in collaborative initiatives such as the Think tank: Mucosal Immunology.
He leads a dedicated research team within the Innate Immunity Unit at the Institut Pasteur, fostering a collaborative environment for studying lymphocyte biology in mice and humans. His laboratory is at the forefront of developing and utilizing humanized mouse models to dissect complex immune responses.
