معرفی
Mathilde Dusseaux serves as Platform Manager at the Institut Pasteur, specifically leading the Human Pathology Models Platform within the Center for Animal Resources and Research. Her work focuses on developing and maintaining humanized immune system mouse models for immunological research.
Dr. Dusseaux's research interests span immunology, humanized mouse models, immuno-oncology, infectious diseases, and translational medicine. She specializes in creating and optimizing BRGS-based human immune system mice (BALB/c Rag2-/- IL-2Rγc-/- SIRPα NOD), including specialized variants like BRGS-A2DR2, BRGST, and BRGSF that enhance specific immune cell functions and responses. Her expertise enables researchers to study human immune responses in vivo across various disease contexts.
Analysis of Dr. Dusseaux's publication record reveals a strong focus on advancing humanized mouse models for immunological research. Her work demonstrates progression from foundational model development to increasingly sophisticated applications in cancer immunotherapy, infectious disease modeling, and vaccine development. Recent publications highlight her contributions to understanding T cell responses in tumor environments and developing next-generation cell therapies.
Dr. Dusseaux actively collaborates with multiple research units at Institut Pasteur, particularly with James Di Santo's Innate Immunity Unit which developed the foundational mouse models she works with. Her platform provides critical infrastructure for immunological research across the institute.
As Platform Manager, Dr. Dusseaux oversees the production and humanization of various immunodeficient mouse models, offering both standard and customized services to researchers. Her team provides in vivo pharmacology studies under specialized conditions (EOPS or A3) and supports investigators in designing and executing experiments using these sophisticated models.
