معرفی
Michaela Müller-Trutwin is a leading researcher at the Institut Pasteur in Paris, France, where she heads a research unit focused on understanding the immunological control of HIV replication and chronic inflammation. She is a Principal Investigator on multiple key projects related to HIV remission, viral reservoirs, and immune regulation. Her work bridges fundamental immunology and clinical applications, contributing significantly to the global effort toward an HIV cure and vaccine.
- Institut Pasteur, Department of Virology, Paris, France
- Principal Investigator, Vaccine Research Institute (VRI Labex)
- Coordinator, European Network on Myeloid Regulatory Cells (Mye-EUNITER), France
- Coordinator, ANRS-MIE research projects on HIV control and inflammation
Education:
- PhD in Science, Université Paris Diderot
- Biology studies, Universities of Bonn and Frankfurt, Germany
Her research centers on the mechanisms enabling rare individuals to control HIV naturally. She investigates the interplay between innate and adaptive immunity, epigenetic modulation during infection, and metabolic regulation of HIV. Her lab uses patient cohorts and non-human primate models to identify biomarkers of HIV remission and chronic inflammation. She has contributed to major discoveries in post-treatment control and immune correlates of protection.
The 15 most recent publications highlight a strong focus on HIV immunopathogenesis, viral persistence, immune control mechanisms, and therapeutic strategies. Key themes include CD8+ T cell responses, NK cell function, broadly neutralizing antibodies, stem cell transplantation for HIV cure, and myeloid regulatory cells. Her work frequently appears in high-impact journals such as Nature Medicine, Nature Immunology, and Cell Host & Microbe.
Scientific Awards and Recognitions:
- No specific awards mentioned in the provided text.
Advising and Grants:
- Supervised multiple PhD students and postdoctoral researchers, including Simon Jochems, Aurélio Orta-Resendiz, and Alice Bongers.
- Principal Investigator on major funded projects: VRI Labex, Mye-EUNITER (EU COST Action), ANRS-MIE cohorts (NICE, PRIMO), and studies on NK cells and chronic inflammation.
- Active in international collaborations, particularly through France-Japan symposia and EU research networks.
Laboratories and Research Teams:
She leads a multidisciplinary team at the Institut Pasteur comprising permanent researchers, technicians, PhD students, postdocs, and administrative staff. Her laboratory is integrated within the Department of Virology and collaborates closely with the Vaccine Research Institute and the Center for Immunotherapy. The team operates within a robust ecosystem of core facilities and national/international consortia focused on HIV and infectious diseases.
