معرفی
Qiou Wei, PhD, is an Associate Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky. Their research focuses on understanding how reactive oxygen species (ROS) contribute to carcinogenesis and cancer progression, with particular emphasis on the molecular mechanisms of sulfiredoxin and peroxiredoxin proteins in cancer metastasis. Current work explores the Srx-Prx4 axis's role in tumor invasion using experimental strategies including cell culture, gene manipulation, and mouse models.
Education: PhD (specific details not provided in text)
Research Interests: Dr. Wei's lab investigates oxidative stress signaling pathways, redox regulation in cancer cells, and the interplay between environmental carcinogens and cellular responses. Key areas include:
- Mechanisms of sulfiredoxin-mediated EGFR signaling activation
- Peroxiredoxin IV's role in radioresistance and tumor progression
- Redox-dependent metastatic pathways in lung and colorectal cancers
Publications Overview: Recent work highlights studies on:
- Artesunate's synergistic effect with enzalutamide in prostate cancer
- Sulfiredoxin-Prx4 interactions in lung and colorectal carcinogenesis
- PRX4's involvement in ferroptosis regulation and inflammation
Advising & Training: Open positions for motivated students and postdocs in cancer biology and redox signaling. Experimental techniques include protein-protein docking, mouse carcinogenesis models, and signaling pathway analysis.
Laboratory Focus: The lab employs multidisciplinary approaches combining molecular biology, biochemistry, and in vivo models to dissect cancer progression mechanisms. Current projects aim to identify novel therapeutic targets in ROS-driven cancers.
