معرفی
Pete Calabresi is Professor of Neurology at the Johns Hopkins University School of Medicine, where he leads a dynamic research laboratory focused on the neurobiology of multiple sclerosis (MS) and CNS demyelination. His work bridges fundamental neuroscience and clinical neurology, with a focus on understanding how immune cells impair remyelination and drive neurodegeneration.
His research interests include:
- Neuroimmunology of MS
- Endogenous remyelination mechanisms
- Glial cell biology (astrocytes, oligodendrocytes, microglia)
- Neurodegeneration and axonal injury
- Metabolomics and biomarker discovery in neurological disease
- Human iPSC-based disease modeling
Dr. Calabresi's recent publications reveal a strong trend toward integrating advanced technologies—such as spatial transcriptomics, CEST MRI, and iPSC models—to dissect the molecular and cellular mechanisms of CNS injury in MS. His work frequently explores immune-glial crosstalk, with a focus on T cell modulation of oligodendrocyte precursor cells and the role of reactive astrocytes in neurotoxicity.
His research is generously supported by:
- National Institutes of Health (R01NS041435, R01NS082347, U01NS111678)
- Department of Defense (W81XWH1910622)
- National Multiple Sclerosis Society (NMSS 1907-34756, NMSS 1904-33800)
Dr. Calabresi actively mentors graduate students and postdoctoral fellows, including Leslie Kirby and Jaime Gonzalez Cardona. He leads a multidisciplinary team comprising research associates, clinical fellows, laboratory managers, and research technologists. His lab's collaborative approach integrates animal models, human tissue analysis, and cutting-edge imaging to advance neuroprotective and reparative strategies for MS.
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