معرفی
Gordon P. Meares is an Associate Professor at the Rockefeller Neuroscience Institute within the School of Medicine at West Virginia University. His research focuses on neuroimmunology, specifically the cellular and molecular mechanisms regulating inflammation in the central nervous system (CNS) and its role in neurological diseases such as Multiple Sclerosis.
Education:
- PhD, University of Alabama at Birmingham, 2007
- BS, Auburn University, 2001
Dr. Meares' laboratory investigates inflammatory responses in glial cells (astrocytes and microglia) to metabolic stress and injury, and their impact on other CNS cell types. His primary research areas include AMPK/LKB1 signaling in neuroinflammation for Multiple Sclerosis, PERK-dependent inflammatory pathways in ER stress, and transcriptome-wide mapping of neuroinflammatory responses using RNA-seq and bioinformatics. His work bridges molecular mechanisms with therapeutic applications for neurodegenerative conditions.
Analysis of Dr. Meares' 12 publications (2011-2017) reveals a dominant focus on ER stress-induced neuroinflammation, particularly the PERK-JAK-STAT and AMPK regulatory pathways. His research consistently links molecular signaling in glial cells to disease mechanisms in Multiple Sclerosis and neurodegeneration, with strong emphasis on translational potential through conditional knockout models and primary cell cultures.
Dr. Meares currently mentors graduate students in his laboratory and is accepting new trainees. His research is funded by a National Multiple Sclerosis Society (NMSS) grant investigating AMPK/LKB1 signaling in EAE models of MS.
He is an active member of the Center for Neuroscience and the Center for Basic and Translational Stroke Research at West Virginia University. His laboratory employs advanced techniques including conditional knockout mice, primary glial cultures, in vivo cell-specific RNA labeling, and next-generation sequencing to dissect neuroinflammatory mechanisms.
