معرفی
Peili Gu is a Senior Research Scientist in the Department of Laboratory Medicine at Yale University School of Medicine. He holds a PhD from the University of Hong Kong (2000), an MSc from the Chinese Academy of Sciences (1990), and a BS from East China University of Science and Technology (1985). His research focuses on telomere biology, including telomere maintenance mechanisms, telomerase regulation, and their roles in cancer and genetic diseases such as Coats plus. Key areas of investigation include the functions of POT1, CTC1-STN1, and SLX4 proteins in telomere protection, DNA repair, and genomic stability. Collaborations with researchers like Sandy Chang, Taylor Takasugi, and Rekha Rai highlight his interdisciplinary approach to understanding telomere dysfunction in tumorigenesis and cancer therapy targets. His work has contributed to identifying synthetic lethal targets in microsatellite unstable cancers and elucidating structural insights into telomere-binding proteins.
Publications since 2023 emphasize mechanisms of telomere hyper-elongation in tumors and the role of G-quadruplex-induced DNA damage. Earlier work from 2010 to 2013 explored miRNA regulation in embryonic stem cells and epigenetic repression of pluripotency genes. This research bridges molecular biology, genetics, and oncology to advance understanding of telomere-related diseases and cancer biology.
