معرفی
Noa Lamm-Shalem is a Conjoint Senior Lecturer affiliated with the Children's Medical Research Institute at the University of Sydney's Faculty of Medicine and Health. Her email is noa.lamm-shalem@sydney.edu.au.
Her research focuses on replication stress, DNA repair mechanisms, and telomere biology, with particular emphasis on how these processes impact genomic stability and cancer development. She investigates topics such as nuclear F-actin dynamics, the role of POT1 dysfunction in telomere relocalization, and the interplay between mTOR signaling and DNA replication.
Current research student Deborah CHANDRA is investigating the role of nuclear F-actin in Alternative Lengthening of Telomeres (ALT).
Key grants include:
- 2020: Ataxia-Telangiectasia: An emerging role for inflammation in driving neurodegeneration and premature ageing, funded by NHMRC Ideas Grant.
- 2017: Targeting novel pathways in the DNA replication-stress response to kill cancer cells, Cancer Institute NSW Early Career Fellowship.
- 2016: Targeting condensin II complex to induce lethality in cancer cells via replication stress, mitotic catastrophe and telomere deprotection, DVC Research Bridging Support Grant.
Lamm-Shalem’s work bridges molecular genetics, cell biology, and cancer research, with a focus on translational applications in therapeutic strategies targeting replication stress pathways.
