معرفی
Professor Hilda Pickett is Head of the Telomere Length Regulation Unit at the Children's Medical Research Institute (CMRI) and holds a conjoint professorship at the University of Sydney. Her research focuses on telomere biology, particularly the molecular mechanisms of telomere length control, genomic stability, and cellular immortality in cancer.
- PhD, University of Leicester, UK
- Postdoctoral experience: Cancer Research UK (Leeds) and CMRI, Australia
Research Highlights:
- Mechanisms of Alternative Lengthening of Telomeres (ALT) in cancer cells
- Telomere replication stress and its role in disease
- Development of telomere-specific therapeutic strategies
- Investigations into RNA-binding proteins in telomerase activity
Recent Publications demonstrate expertise in telomere dynamics, DNA repair pathways, and cancer genomics across multiple journals like Nature Structural and Molecular Biology and Science. Key trends include targeting ALT mechanisms for cancer therapy, telomere stress markers, and genomic instability in sarcomas.
Scientific Grants include funding from the US Department of Defence, Australian Department of Health, and NHMRC for projects like "Prevention of bone marrow failure in Fanconi anemia" and "Alternative Lengthening of Telomeres (ALT): Target Discovery to Treatment."
Students advised include
- Deborah Nazareth: Recombinant AAV vector design for hepatocellular carcinoma
- Jake Schwenke: Synthetic lethality with FANCM inhibition in ALT-negative cancers
