معرفی
Dr Alexander Sobinoff is a Conjoint Senior Lecturer (Level C) at the University of Sydney’s Faculty of Medicine and Health and a Research Fellow at the Children’s Medical Research Institute. He holds a PhD and has over a decade of research experience specializing in molecular and cellular biology, with a focus on telomere biology, genome stability, and DNA repair mechanisms. His work has pioneered methods to analyze telomere extension and identified key therapeutic targets for ALT cancers.
Dr Sobinoff completed his PhD thesis in under three years, earning the Research Higher Degree Submission Award in 2012. Earlier recognitions include the Science and Information Technology Outstanding Postgraduate Student Achievement Award (2011) and the Oozoa Biomedical Inc Oozoa Student Award (2010).
His research investigates how cancer cells resolve toxic DNA repair intermediates, particularly through mechanisms involving the Alternative Lengthening of Telomeres (ALT) pathway. Current projects prioritize understanding DBHS proteins, anaphase bridge resolution, and telomerase recruitment in cancer and stem cells. His lab employs advanced tools like siRNA-resistant mutants, knockout cell lines, and small molecule inhibitors to dissect these processes.
Key awards include the 2025–2027 Children’s Medical Research Institute Fellowship and the 2018–2020 Cancer Institute NSW Early Career Fellowship. Notable contributions also include the Elizabeth Blackburn Prize (2014) and the Eppendorf Postdoctoral Award (2017).
Dr Sobinoff advises research student Jake Schwenke on synthetic lethality in ALT-negative cancers. His grants include projects targeting TRF2 proteins (Cancer Institute NSW, 2017), telomere length measurement (Cancer Australia, 2016), and the Prof. Tony Basten Fellowship (2014). His work is conducted within a multidisciplinary lab at the Children’s Medical Research Institute.
