معرفی
Pei-Yu Chen is a Senior Research Scientist in the Department of Cardiovascular Medicine at Yale School of Medicine. She holds a PhD from the University of Maine (2009) and specializes in elucidating mechanisms underlying cardiovascular diseases, including atherosclerosis, aortic aneurysms, and vascular inflammation. Her work focuses on TGFβ signaling, endothelial-to-mesenchymal transition (EndMT), and the role of FGF and mTOR pathways in vascular pathologies. Recent efforts aim to develop safer drug delivery methods targeting these pathways.
Research Interests: Chen's studies integrate molecular biology and translational approaches to understand how cellular signaling cascades drive vascular disease progression. Key areas include:
- TGFβ and FGF pathway cross-talk in endothelial dysfunction
- Mechanisms of smooth muscle cell phenotypic switching
- Role of mTOR in vascular inflammation and remodeling
- Preclinical models for atherosclerosis and aneurysm studies
Publications Highlight: Her recent articles (2020-2023) emphasize TGFβ inhibition strategies, EndMT regulation, and mTOR pathway interventions. A 2023 study proposed novel therapeutic approaches targeting TGFβ signaling in cardiovascular diseases.
Awards: No specific honors listed, though her research has been highlighted in Yale Medicine articles for innovative drug delivery concepts.
Collaborations: Works closely with cardiovascular teams at Yale School of Medicine, focusing on preclinical drug development and vascular biology.
