معرفی
Divyesh Joshi is an Associate Research Scientist in the Department of Internal Medicine at Yale School of Medicine, affiliated with the Schwartz Lab. His research focuses on mechanobiology, cytoskeletal dynamics, and cardiovascular development, with emphasis on endothelial flow sensing and molecular mechanisms underlying vascular patterning. He employs advanced imaging techniques and genetic models to study how mechanical forces and molecular interactions regulate vascular health and disease.
Key research themes include Rudhira/BCAS3 protein’s role in cytoskeletal regulation and TGFβ signaling, super-resolution imaging using host-guest chemistry, and mechanotransduction pathways in atherosclerosis. His work bridges cell biology, molecular genetics, and biomedical engineering to understand vascular physiology and disease progression.
Recent studies highlight endothelial cell cycle regulation in artery remodeling and the role of Polycomb complexes in atherosclerotic plaque vulnerability. Collaborations include work with Martin Schwartz and teams at Yale, exploring mechanosensitive pathways in endothelial cells.
