Paul Rosenberg

Paul Rosenberg is an Associate Professor of Neurology at Harvard Medical School and a Senior Associate in the Department of Neurology at the Waltham Sleep Center. His research focuses on neurodegenerative diseases, brain injury in premature infants, sleep mechanisms, and glutamate signaling. He holds an MD from Albert Einstein College of Medicine (1978) and a PhD, with residency training at Longwood Area Neurological Training Program (1982) and a fellowship at Boston Children's Hospital (1985).

Rosenberg's research spans neurodegeneration (Alzheimer's, Huntington's), excitotoxic mechanisms, and the role of glutamate transporters like GLT-1. His work also addresses oxidative stress, zinc homeostasis, and developmental neurobiology. Clinically, he combines sleep medicine practice with neurology, emphasizing translational research.

Key areas of study include the pathophysiology of periventricular leukomalacia, cerebral white matter injury, and the interplay between glutamate transport and neurodegeneration. His findings on GLT-1's role in synaptic and mitochondrial function have advanced understanding of excitotoxic injury and therapeutic targets.

Publications highlight his contributions to glutamate transporter biology, neurovascular reactivity in Alzheimer's, and the redox mechanisms of excitotoxicity. Rosenberg's work bridges basic science and clinical applications, particularly in neuroprotection strategies for neurodegenerative and developmental disorders.