معرفی
John H. Weiss is a Professor in the Departments of Neurology and Anatomy & Neurobiology at the School of Medicine, University of California, Irvine. His research focuses on mechanisms of neurodegeneration, particularly the roles of glutamate receptors (AMPA/kainate), zinc (Zn²⁺), and calcium (Ca²⁺) in neuronal injury. His work spans ischemic stroke, Alzheimer’s disease, ALS, and other neurological disorders, emphasizing mitochondrial dysfunction and excitotoxicity.
Education:
- MD, Stanford University, 1983
- PhD, Stanford University, 1991
Research Interests:
- Neurodegeneration mechanisms
- Zn²⁺ and Ca²⁺ signaling in neuronal injury
- Excitotoxicity pathways
- Ischemic brain injury
- Therapeutic strategies targeting mitochondrial dysfunction
Publications: Dr. Weiss has authored over 100 peer-reviewed articles, with recent work emphasizing Zn²⁺’s role in mitochondrial dysfunction during ischemia and the development of neuroprotective therapies.
Awards:
- Christopher J. Frederickson Prize (2014)
- PEW Scholar in Biomedical Sciences (1991–1996)
- NIH Clinician Investigator Award (1990–1995)
Grants & Labs: His lab at the Gillespie Neuroscience Research Facility investigates neurodegenerative mechanisms, with funding from NIH and private foundations. Collaborations include studies on mitochondrial Zn²⁺ accumulation and ALS pathogenesis.
