Pao-Sheng Chang

Dr. Pao-Sheng Chang is a Guarantors of Brain Postdoctoral Research Fellow at the University of Oxford's Nuffield Department of Clinical Neurosciences within the Medical Sciences Division. He is affiliated with the Neuromusculoskeletal Health and Science Lab and Neural Injury Group, and is a member of Exeter College.

His educational background includes:

• DPhil in Clinical Neurosciences from the University of Oxford
• MRes in Translational Neurology from University College London (UCL)
• BSc in Life Science from National Tsing Hua University

Dr. Chang's research focuses on neuro-immune mechanisms in human neuropathic pain, specifically investigating glucocorticoid-induced macrophage subpopulations (M_GC) using humanized co-culture models and injured human nerves. His work spans multiple peripheral neuropathies including Morton's neuroma and painful diabetic neuropathy, with the long-term goal of translating discoveries into pharmaceutical treatments for neurological disorders. His methodology combines advanced techniques like human induced pluripotent stem cell-derived sensory neurons and microfluidic coculture platforms.

His recent publications demonstrate a clear trajectory toward human-relevant pain research, shifting from animal models to human tissue analysis. The 2024 publications particularly emphasize molecular signatures of neuropathic pain and neuro-immune interactions using innovative humanized in vitro systems, reflecting a strategic move toward clinically translatable findings.

Dr. Chang has received the prestigious Guarantors of Brain Postdoctoral Fellowship, which supports his research on developing macrophage-specific pain treatments with potential clinical application within the next decade.

As a postdoctoral research fellow, Dr. Chang leads laboratory investigations while collaborating with clinical teams. His fellowship provides dedicated resources for exploring neuro-immune interactions in human nerve tissue, with particular emphasis on single-cell transcriptomics and cell-cell communication mechanisms.

Within the Neuromusculoskeletal Health and Science Lab and Neural Injury Group, Dr. Chang contributes to a multidisciplinary environment that bridges basic neuroscience, immunology, and clinical neurology, focusing on understanding nerve injury mechanisms and developing novel therapeutic approaches for neuropathic conditions.