Nitin Pandey

Nitin Pandey, PhD is an Assistant Professor of Research in Physiology and Neuroscience at the University of Southern California. His research focuses on protein aggregation mechanisms in neurodegenerative diseases, particularly huntingtin exon-1 and TDP43 proteins linked to Huntington's and ALS/FTD diseases. He investigates fibril formation pathways, conformational interactions, and small molecule inhibitors using advanced biophysical techniques.

• Expertise: Protein aggregation, neurodegenerative diseases, amyloid fibrillogeneis, molecular biophysics
• Key methodologies: Fluorescent tagging, FRET-based screening, structural characterization

Recent work includes discovering conformational interactions between TDP43 and huntingtin proteins altering fibril formation, and identifying lipid-modulated membrane binding mechanisms of huntingtin. His studies also explore copper's role in aggregation pathways and molecular inhibitors targeting toxic assemblies.

Over 25 peer-reviewed publications span molecular mechanisms of protein aggregation in neurodegenerative contexts, with recent emphasis on cellular models of HTTex1 toxicity and membrane-protein interactions. No specific awards or grants are listed in available information.