Hilal Lashuel

Hilal Lashuel is a Professor at the École Polytechnique Fédérale de Lausanne (EPFL), affiliated with the School of Life Sciences (SV) and the Department of Life Sciences Engineering. His research focuses on neurodegenerative diseases, particularly the molecular mechanisms underlying protein aggregation in Alzheimer's, Parkinson's, and Huntington's diseases. He leads the Lashuel Lab, which investigates protein post-translational modifications, amyloid fibril formation, and the development of biomarkers and therapeutic strategies.

• Roles: Honorary Professor, Leading neurodegeneration research group at EPFL.
• Affiliations: EPFL SV-SSV (Teaching Unit), SV-DEC (Departmental Council).
• Research Interests: Protein aggregation, alpha-synuclein, tau, huntingtin, post-translational modifications, drug discovery, and biomarker development.

His work combines biochemical, biophysical, and computational approaches to elucidate how proteins misfold and aggregate, contributing to neurodegenerative pathologies. Key achievements include groundbreaking studies on alpha-synuclein's role in Parkinson's disease, the structural diversity of amyloid fibrils, and the development of novel inhibitors targeting protein aggregation.

Publications: Over 200 peer-reviewed articles, including high-impact studies in Science Advances, Nature Neuroscience, and Cell. Recent work focuses on multi-targeting peptides, nanoplasmonic sensors for protein biomarkers, and structural insights into amyloid polymorphism.

Grants & Awards: Extensive funding from national and international agencies, though specific awards are not explicitly listed.

Labs/Teams: Directs the Lashuel Lab, collaborating with global institutions on neurodegenerative disease research, including projects on drug development and early diagnosis strategies.