معرفی
Nadia Naffakh is a permanent researcher at the Institut Pasteur in Paris, affiliated with the Stroma, inflammation and tissue repair group within the Department of Biochemistry and Chemobiology. She leads multiple research projects focused on influenza virus molecular biology, including viral RNA trafficking, transcription mechanisms, and host-pathogen interactions. Her work is highly collaborative, involving partnerships with institutions such as EMBL Grenoble and CSIC Madrid.
- University: Institut Pasteur
- School: Stroma, inflammation and tissue repair
- Department: Biochemistry and Chemobiology
- Position: Researcher
- Email: nadia.naffakh@pasteur.fr
Her research focuses on the molecular mechanisms of influenza virus replication, particularly how the virus hijacks host cellular machinery such as RNA polymerase II. She also investigates host factors influencing viral susceptibility across populations, including differences in monocyte responses between individuals of African and European ancestry. Her lab employs cutting-edge techniques such as engineered tagged viruses and high-throughput screening assays.
The recent publications (2018–2024) reflect a strong emphasis on viral transcription, RNA processing, host interactions, and antiviral strategies, including work on SARS-CoV-2. Topics span from basic virology to drug discovery, indicating a broad and impactful research program.
Scientific Contributions:
- Elucidated the role of host RNA polymerase II CTD in influenza genome replication.
- Developed sensitive luciferase assays for antiviral screening.
- Demonstrated population-level differences in innate immune responses to influenza.
- Explored host splicing machinery as a target for anti-influenza therapy.
Nadia Naffakh mentors several PhD students and postdoctoral researchers and is actively involved in the Chemogenomic and Biological Screening Platform (PF-CCB) and the ATC-DDS initiative at the Institut Pasteur. She has not received any explicitly mentioned scientific awards in the provided texts, but her publication record in high-impact journals underscores her scientific leadership. Her laboratory contributes significantly to understanding viral pathogenesis and developing novel therapeutic approaches.
