معرفی
Caroline Demeret is a researcher and Principal Investigator at the Institut Pasteur in Paris, leading the project on the interplay between influenza virus and the ubiquitin/proteasome system. She is also the Structure Manager Responsible for the team focused on Structural Biology of Virus-Host Interactions.
Her research focuses on understanding how viruses, particularly influenza A and SARS-CoV-2, manipulate host cellular machinery, especially the ubiquitin-proteasome system, to promote replication. Her work involves advanced proteomic techniques such as affinity purification mass spectrometry (AP-MS) and split-luciferase assays to map virus-host protein interactomes. She investigates how viral infection rewires host protein interaction networks, with implications for developing host-targeted antiviral therapies.
Her recent publications highlight her contributions to mapping the SARS-CoV-2-human interactome in 3D and profiling the dynamic changes in Cullin4-E3 ligase complexes during influenza infection. These studies provide insights into viral strategies for hijacking cellular processes and identify potential therapeutic targets.
She has collaborated on numerous high-impact studies related to SARS-CoV-2 serology, immunity, and transmission, contributing to public health understanding during the pandemic.
- Principal Investigator, Interplay between influenza virus and the ubiquitin/proteasome system
- Structure Manager Responsible, Structural biology of virus-host interactions
- Active researcher in virology, molecular biology, and proteomics
Caroline Demeret leads a research team at the Institut Pasteur, focusing on virus-host interactions and employing cutting-edge proteomic and molecular techniques to uncover mechanisms of viral pathogenesis and identify potential antiviral strategies.
