معرفی
A.J. te Velthuis is an Assistant Professor of Molecular Biology at Princeton University, leading the te Velthuis Lab focused on RNA virus replication and innate immune sensing. His research explores how RNA viruses like influenza and SARS-CoV-2 amplify, mutate, and trigger immune responses. He holds a Ph.D. in Molecular Virology from Leiden University and a B.Sc. in Biology.
Key research areas include viral RNA polymerase mechanisms, antiviral strategies, and host-pathogen interactions. He has pioneered studies on mini viral RNAs that activate innate immunity and discovered novel flu RNAs that trigger RIG-I signaling. His work integrates biochemical, structural, and single-molecule techniques.
- Awards: NIH DP2 Award (2023), Wellcome Trust Henry Dale Fellowship (2017)
- Funding: NIH R01 grants (AI170520, AI177487), NSF fellowships, Princeton Catalysis Initiative
- Labs: Located in Lewis Thomas Laboratory 101, emphasizing green lab practices with a Platinum Sustainability Certificate
- Grants: Manages NIH DP2, R21, and multiple institutional grants supporting viral replication studies
His team collaborates widely, with recent preprints from students Karishma Bisht and Caitlin Lamb. Ongoing work includes screening immune-activating RNAs in patients and investigating antiviral drug mechanisms.
