Anna Marie Pyle

Anna Marie Pyle is a Sterling Professor at Yale University in the Departments of Molecular, Cellular and Developmental Biology and Chemistry. She is a Howard Hughes Medical Institute Investigator since 1997 and has held leadership roles including President of the RNA Society and Chair of the NIH MSFA Study Section. Her research focuses on RNA structure, RNA remodeling enzymes, and innate immune receptors. She has authored over 190 publications and mentored over 40 students/postdocs.

**Education:** B.S. in Chemistry (Princeton University), Ph.D. in Chemistry (Columbia University, 1990). Postdoctoral training at the University of Colorado with Thomas Cech. Joined Yale in 2002.

**Research:** Pioneered structural studies of group II introns and the spliceosome. Her lab investigates RNA tertiary structures, viral RNA biology, and RIG-I signaling. Key contributions include understanding RNA helicases, antiviral immunity, and lncRNA structural biology. Collaborates with industry (e.g., Arrakis Therapeutics) on RNA-based therapeutics.

**Awards:** HHMI Investigator, National Academy of Sciences member, AAAS Fellow. Recognized for innovations in RNA structure-function relationships.

**Grants & Labs:** Leads the Pyle Lab at Yale, funded by NIH and HHMI. Active in developing RIG-I agonists for cancer immunotherapy and antifungal drugs targeting RNA splicing.