معرفی
Alexandra Bergfort is a Research Fellow in the Neugebauer Lab at the Yale School of Medicine, Yale University. She holds a PhD in Biochemistry from Freie Universität Berlin (2020). Her research focuses on RNA processing mechanisms, particularly the interplay between RNA splicing, polyadenylation, and protein interactions in gene expression regulation.
Education:
- PhD in Biochemistry, Freie Universität Berlin, 2020
Research Interests: Bergfort investigates molecular processes governing RNA maturation, including alternative polyadenylation site selection, spliceosome dynamics, and the role of intrinsically disordered proteins in snRNP assembly. Her work integrates biochemistry and molecular genetics to elucidate how these mechanisms impact cellular function and disease pathogenesis.
Recent Work Trends: Recent publications emphasize protein-RNA interactions (e.g., TSSC4's role as a helicase inhibitor) and the regulatory roles of spliceosome components like BRR2 in diseases linked to alternative splicing defects, such as neurodegenerative disorders.
Lab Affiliation: Neugebauer Lab, focused on RNA biology and gene expression regulation.
