James Manley

James Manley is the Julian Clarence Levi Professor of the Life Sciences at Columbia University, with extensive research in gene expression regulation. His work spans transcription, RNA splicing, and polyadenylation mechanisms in human cells, connecting these processes to neurodegenerative diseases (ALS/FTD) and cancers.

• Affiliation: Columbia University, Department of Biological Sciences
• Contact: jlm2@columbia.edu

Research Interests: Dr. Manley's laboratory investigates nuclear processes including:

• Transcriptional control via RNA polymerase II CTD modifications
• Alternative splicing regulation by hnRNP and SR proteins
• Polyadenylation dynamics in cell cycle and differentiation
• Disease mechanisms in spliceosome mutations (SF3B1, SRSF2)
• RNA-protein interactions in stress responses

Publication Trends: Recent work focuses on disease-associated mutations affecting RNA processing, non-canonical RNA functions, and immune regulation via polyadenylation. Articles span molecular oncology, neurodegeneration, and RNA surveillance mechanisms.

Scientific Recognition:

• Member, American Academy of Arts & Sciences
• Member, National Academy of Sciences

Key Collaborations: Studies involve interdisciplinary work with neurology, cancer biology, and immunology teams. His lab employs biochemical assays, structural analysis, and genetic models to dissect RNA processing pathways.