Douglas Black

Douglas Black is a Professor in the Department of Microbiology, Immunology & Molecular Genetics at the University of California, Los Angeles (UCLA), affiliated with the College of Life Sciences. He investigates RNA processing and alternative splicing, focusing on their roles in neuronal diversity and diseases like cancer and neurodegeneration.

• Research Focus: Regulation of pre-mRNA splicing, splicing regulators (PTBP1, PTBP2, RBFOX proteins), RNA biology, and transcriptomic impacts on health.
• Key Contributions: Elucidation of splicing mechanisms (e.g., SF3B1 mutations, LASR complex function) and therapeutic applications (splice-modifying drugs, RNA sensors).

Recent Publications highlight mechanisms of splicing in cancer, neurodevelopment (RBFOX1/LASR), GBA1 mutations in neurodegeneration, and RNA localization (Malat1). Awards and education details were not explicitly mentioned.