Anastasia V. Komarova

Anastasia V. Komarova is a Permanent Researcher at the Institut Pasteur-Oncovita Joint Laboratory, focusing on:

• Developing measles vaccine vector-based immunotherapies for aggressive solid tumors (triple-negative breast cancer, mesothelioma)
• Creating multi-disease vaccines against WHO high-priority pathogens
• Decoding virus-host interactions through proteomics and RNA biology

Her work leverages the measles vaccine's immunogenicity to produce:

• Therapeutic candidates triggering RIG-I-mediated apoptosis in cancer cells (MVdeltaC)
• Universal vaccine platforms replacing multiple pediatric vaccines
• Mechanistic insights into HIV-1 and measles virus immune modulation

Recent publications reveal:

• Conserved Y RNA-RIG-I interactions across RNA viruses
• Measles virus proteins disrupting mitochondrial networks and interferon pathways
• Defective viral RNA as innate immune agonists

Collaborations with Oncovita enable industrial translation of these discoveries.