معرفی
Moua Yang, Ph.D. is an Academic Assistant Professor in the Division of Hematology and Oncology at the University of Washington School of Medicine and an Assistant Member at the Bloodworks Northwest Research Institute in Seattle, Washington. His research focuses on redox mechanisms in thrombosis, with particular emphasis on oxidative cysteine modifications and thiol isomerases in clot formation.
Dr. Yang received his undergraduate degree from the University of Wisconsin-Stevens Point, followed by a Ph.D. from the Medical College of Wisconsin. He completed postdoctoral training at the Medical College of Wisconsin and later at Beth Israel Deaconess Medical Center and Harvard Medical School.
Dr. Yang's primary research investigates the redox mechanisms that promote thrombosis, with specific focus on oxidative cysteine modification and its role in thrombotic machinery. His laboratory employs chemical biology, protein biochemistry, and real-time intravital imaging to unravel these mechanisms. He also studies thiol isomerases - enzymes that function to make and break disulfides during protein folding - which escape into the bloodstream and play critical roles in clot formation. His research explores how these enzymes promote thrombus formation in oxidative stress conditions, with specific areas of study including mechanisms of vaso-occlusion by thiol isomerases and natural compounds as anti-thrombotics.
Analysis of Dr. Yang's recent publications reveals a strong focus on redox biology in thrombosis, with particular emphasis on cysteine oxidation, thiol isomerases, and CD36 signaling pathways. His work spans basic mechanisms of thrombosis, translational applications for antithrombotic therapy, and even extends to research on high-altitude physiology and diversity in STEMM fields. A notable trend is his exploration of natural compounds, particularly polyphenols, as potential antithrombotic agents targeting redox-sensitive pathways.
Dr. Yang leads a research laboratory at Bloodworks Northwest Research Institute, where he mentors research technologists including Osamede C. Owegie and John K. Ryan. His laboratory investigates the molecular mechanisms of thrombosis with applications for developing novel antithrombotic therapies.
