Michael Sofroniew

Michael Sofroniew is a Professor in the Department of Neurobiology at the David Geffen School of Medicine, University of California, Los Angeles. His research focuses on understanding the cellular and molecular mechanisms of astrocyte reactivity in CNS injury, neuroinflammation, and regeneration. Key areas include neuroprotection, scar formation, and transcriptional regulation in transgenic mouse models.

His recent work explores astrocyte immune memory, reactive subtypes in stroke and spinal cord injury, and biomaterials-based delivery systems. Collaborations span neuroimmunology, spinal cord repair, and neurodegenerative disease modeling.

Notable trends in his publications include single-cell atlases of CNS injury, CRISPRi-driven inflammatory regulators, and TNF-STAT3 signaling in BBB dysfunction. Current studies emphasize precision targeting of astrocyte responses and scar-modulating therapies.

His laboratory at the Neuroscience Research Building employs techniques like microsurgery, immunohistochemistry, and molecular biology to dissect glial roles in health and disease.