Michael Victor Sofroniew

Michael Victor Sofroniew is a Professor in the Department of Neurobiology at the David Geffen School of Medicine, University of California, Los Angeles (UCLA). His research focuses on reactive astrocytes, their roles in central nervous system (CNS) damage and disease, and their potential as therapeutic targets.

• Education: Ludwig-Maximillians University, Munich (MD, 1981); University of Oxford (DPhil, 1984)

Research Interests: Sofroniew investigates astrocyte reactivity in spinal cord injury (SCI), stroke, neurodegeneration, and inflammation. His work explores mechanisms like STAT3 signaling, glial scar formation, and strategies for CNS repair via axon regeneration and biomaterials.

Article Trends: His recent publications highlight astrocyte heterogeneity, immune interactions, and translational approaches using viral vectors, CRISPRi screens, and hydrogel-based delivery systems. Key themes include in vivo calcium imaging, neuroinflammatory mediators, and regenerative therapies.

Grants: Major funding includes the Adelson Medical Research Foundation (2019-2025) and NIH grants (R01NS084030, R21NS071292, R01NS057624).

Labs and Teams: Sofroniew leads research integrating genomic tools, animal models, and biomaterials to study astrocyte biology. His team collaborates on projects like the Astrocyte Reactivity Regulation Browser and Astrocyte Reactivity Genomics Browser.