معرفی
Michael H. Nathanson, MD, PhD, is the Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology at Yale School of Medicine. He serves as Co-Director of the Yale Liver Center and Director of the Center for Cellular and Molecular Imaging, playing a pivotal role in advancing hepatology and cellular imaging research.
- Department: Department of Medicine (Digestive Diseases)
- School: Yale School of Medicine
- University: Yale University
Research Interests: Dr. Nathanson’s research centers on calcium signaling in liver cells, particularly hepatocytes and cholangiocytes. His work explores how nuclear and mitochondrial calcium dynamics regulate liver function and contribute to diseases such as cholestasis, alcohol-associated hepatitis, and fibrosis. He investigates the molecular mechanisms of inositol trisphosphate receptors and their role in bile secretion and disease pathogenesis.
Recent Research Trends: His recent publications highlight the intersection of calcium signaling, mitochondrial metabolism, and immune regulation in liver disease. Key themes include the role of cytosolic calcium in metabolic regulation, neutrophil-mediated calcium dysregulation in alcoholic hepatitis, and mitochondrial DNA in stellate cell activation. His work increasingly bridges cell biology, immunology, and metabolism.
Scientific Awards and Honors:
- Member, Association of American Physicians (AAP)
- Member, American Society for Clinical Investigation (ASCI)
- FAPESP Fullbright Scholar
Grants and Advising: Dr. Nathanson is the Principal Investigator of multiple NIH grants, including R01s, a P01 program project, and a P30 Digestive Diseases Research Core Center. He also leads a T32 training grant in Hepatology, supporting the development of physician-scientists. He directs core facilities and mentors numerous researchers, contributing significantly to academic training and collaborative science.
Labs and Research Teams: He leads research through the Yale Liver Center and the Center for Cellular and Molecular Imaging, fostering interdisciplinary collaboration. His team frequently partners with experts in metabolism, immunology, and imaging, including Drs. Gerald Shulman, Fred Gorelick, and Barbara Ehrlich.