Marta Toth

Marta Toth is an Assistant Research Professor at the University of Notre Dame, affiliated with McCourtney Hall. Her research focuses on combating antibiotic resistance in Gram-negative bacteria, particularly through structural and kinetic studies of carbapenemases—enzymes that degrade critical β-lactam antibiotics like carbapenems.

• Research Interests
• Medicine
• Biochemistry

Dr. Toth collaborates on projects analyzing class D carbapenemases (e.g., OXA-58, GES-5) and designing novel carbapenemase-stable antibiotics. Her work addresses high-mortality infections caused by pathogens such as Acinetobacter baumannii and Enterobacteriaceae.

Her recent publications highlight mechanistic insights into carbapenemase inhibition, including studies on C5α-methyl-substituted carbapenems and their interactions with enzymes driving drug resistance. These works appear in journals like ACS Infectious Diseases and mBio.

Contact: mtoth1@nd.edu