John Quale

Dr. John Quale serves as Professor of Medicine in the Division of Infectious Diseases at SUNY Downstate Health Sciences University, where he has maintained continuous affiliation since medical school. For over 25 years, he has been an attending physician in Infectious Diseases at NYC Health + Hospitals/Kings County and currently holds the position of hospital epidemiologist at Kings County Hospital.

His educational background includes:

• MD from SUNY Downstate Health Sciences University
• Residency at SUNY Downstate Health Sciences University
• Fellowship at SUNY Downstate Health Sciences University

Dr. Quale's research centers on antimicrobial resistance mechanisms in Gram-negative pathogens, with particular expertise in Klebsiella pneumoniae epidemiology. His work investigates porin channel function, KPC carbapenemase expression, and novel antibiotic combinations to overcome resistance. He also focuses on infection control strategies for multidrug-resistant organisms in hospital settings, leveraging his dual role as clinician and epidemiologist to bridge laboratory findings with clinical practice.

Analysis of his 2016-2018 publications reveals consistent focus on New York City's resistance landscape, particularly tracking KPC-producing K. pneumoniae evolution and evaluating next-generation beta-lactam/beta-lactamase inhibitor combinations. His studies combine in vitro susceptibility testing, molecular characterization, and epidemiological surveillance to address carbapenem-resistant Enterobacteriaceae threats, establishing him as a key investigator in regional antimicrobial resistance dynamics.