Patrice Nordmann

Patrice Nordmann is a Full Professor in the Department of Medicine at the University of Fribourg, part of the Faculty of Mathematics, Natural Sciences and Medicine. His research focuses on antibiotic resistance mechanisms, particularly in Gram-negative bacteria, with an emphasis on beta-lactamase inhibitors, carbapenemase-producing pathogens, and novel antibiotic combinations. He leads studies on rapid diagnostic methods for antimicrobial susceptibility testing and investigates pharmacokinetic/pharmacodynamic interactions of last-resort antibiotics. His work bridges clinical microbiology, molecular biology, and therapeutic innovation to combat multidrug-resistant infections.

Research interests include: antimicrobial resistance mechanisms, beta-lactamase enzymology, antibiotic susceptibility testing methodologies, and pharmacodynamic optimization of combination therapies. Recent studies explore resistance emergence to novel agents like cefiderocol, ceftazidime-avibactam, and meropenem-vaborbactam, as well as cross-resistance patterns in KPC, NDM, and OXA-producing strains.

Key contributions involve developing rapid diagnostic tools such as the Rapid CAZ/AVI NP Test and evaluating synergistic antibiotic pairs against carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. His studies also address epidemiological aspects like plasmid-mediated resistance in veterinary and human clinical settings.

Notable collaborations include genomic analyses of Klebsiella pneumoniae and Acinetobacter baumannii isolates, and investigations into the role of porin modifications and efflux pumps in antibiotic resistance. His work frequently integrates in vitro time-kill models with clinical trial data to inform treatment regimens.