معرفی
Laurent Poirel is a Researcher in the Department of Medicine at the University of Fribourg, Switzerland, affiliated with the Faculty of Mathematics, Natural Sciences and Medicine. His work focuses on antibiotic resistance mechanisms, particularly involving beta-lactamases, carbapenemases, and novel antibiotic combinations. He is actively involved in developing rapid diagnostic tests for detecting multidrug-resistant bacteria and characterizing resistance mechanisms in clinical isolates. His research spans One Health perspectives, examining the spread of antibiotic-resistant pathogens in humans, animals, and the environment.
Research interests include molecular analysis of carbapenemase-producing Enterobacterales (CPE), metallo-β-lactamase inhibitors, and the emergence of resistance to last-resort antibiotics like cefiderocol and aztreonam-avibactam. He collaborates with international groups such as the NARA (Institute for Antimicrobial Resistance and New Antibiotics) to advance diagnostic tools and resistance surveillance strategies. Recent studies highlight the genetic basis of resistance, co-resistance patterns, and the impact of environmental pressures on antibiotic resistance spread.
Publications emphasize the in vitro activity of novel antibiotic combinations, rapid detection methods (e.g., NP tests), and the molecular epidemiology of resistance genes. His work bridges basic science and clinical applications, addressing urgent global health challenges posed by drug-resistant pathogens.
